Polynucleotides vs PRP vs Exosomes: Which Skin-Rejuvenation Treatment Is Right for You?
THE ERA OF REGENERATIVE AESTHETICS
Modern aesthetics is shifting from filler-based correction to biological skin optimisation. Regenerative injectables such as Polynucleotides, PRP (Platelet-Rich Plasma) and Exosomes work at a cellular level—repairing, rejuvenating and revitalising the skin from within rather than simply masking imperfections.
At Dr Kania Clinic in Belgravia and Knightsbridge, these advanced therapies are tailored to restore natural radiance while preserving expression and skin integrity.
1. POLYNUCLEOTIDES — DNA-BASED SKIN REGENERATION
What they are
Polynucleotides (PNs) are purified DNA fragments derived from salmon or trout milt, known for their exceptional bio-compatibility.
How they work
They activate fibroblasts, increase collagen and elastin synthesis, enhance hydration and improve micro-circulation.
Best for:
Fine lines and skin laxity
Dullness or crepey texture
Sensitive or post-procedure skin
Treatment time: 30–45 minutes
Downtime: Minimal to none
Results: Gradual improvement over 4–6 weeks
2. PRP — PLATELET-RICH PLASMA (“VAMPIRE FACIAL”)
What it is
PRP uses a patient’s own blood, spun in a centrifuge to isolate platelet-rich plasma containing growth factors.
How it works
Injected or microneedled into the skin, PRP stimulates cell turnover, collagen formation and tissue repair while improving tone and texture.
Best for:
Early signs of ageing
Under-eye hollowness and dark circles
Post-acne scarring
Treatment time: 45–60 minutes
Downtime: Mild redness (up to 24 hours)
Results: Visible within 2–3 weeks
3. EXOSOMES — NEXT-GEN CELLULAR COMMUNICATION
What they are
Exosomes are nano-sized vesicles derived from stem cells, containing proteins, lipids and genetic messengers that coordinate cellular repair.
How they work
When introduced into the skin, they re-programme aged cells, reduce inflammation and boost collagen regeneration.
Best for:
Advanced ageing and sun damage
Inflammation or post-laser healing
Skin requiring deep rejuvenation
Treatment time: 30–40 minutes
Downtime: None
Results: Progressive radiance over 3–4 weeks
4. COMPARING THE THREE TREATMENTS
FeaturePolynucleotidesPRPExosomesSourceMarine DNAPatient’s own bloodStem-cell derived vesiclesPrimary ActionCollagen stimulation + hydrationGrowth factor activationCellular signalling + repairDowntimeMinimalMild rednessNoneOnset of ResultsGradual (4–6 weeks)2–3 weeks3–4 weeksLongevity6–12 months6 monthsUp to 12 monthsSkin Type SuitabilitySensitive & delicate skinAll typesAgeing or damaged skin
Each therapy is potent alone yet remarkable in combination—for instance, PRP + Exosomes for enhanced regeneration or Polynucleotides + LED for amplified collagen boost.
5. TREATMENT PROTOCOL AND AFTERCARE
At Dr Kania Clinic, every regenerative plan begins with an in-depth consultation assessing skin quality, lifestyle and biological age.
Aftercare guidelines:
Avoid exercise, sauna and heat for 24 hours
Refrain from make-up for 12 hours
No NSAIDs or alcohol for 24 hours to minimise bruising
Mild redness or swelling subsides within hours
Visible radiance typically peaks after two weeks and continues improving with maintenance sessions.
6. CHOOSING THE RIGHT TREATMENT FOR YOU
Polynucleotides: Best for hydration and structural rejuvenation.
PRP: Ideal for natural regeneration and restoring tone.
Exosomes: Perfect for advanced anti-ageing and cellular repair.
Your bespoke plan may integrate two or more modalities depending on your skin’s condition, healing capacity and desired result.
7. WHY CHOOSE DR KANIA CLINIC
Expertise in Regenerative Medicine – Doctor-led protocols backed by clinical evidence.
Personalised Diagnostics – Each treatment guided by hormone and metabolic assessment.
Discreet Luxury Environment – Located in Belgravia and Knightsbridge.
Scientific Integrity + Aesthetic Precision – Natural, balanced outcomes without over-correction.
CONCLUSION: A NEW STANDARD IN SKIN REJUVENATION
Regenerative injectables like Polynucleotides, PRP and Exosomes represent the future of aesthetic medicine — bio-restorative treatments that rebuild rather than replace.
At Dr Kania Clinic, we combine scientific expertise with artistry to design bespoke protocols for radiant, resilient skin that ages gracefully.
Book your consultation today to discover which regenerative approach best matches your skin’s needs and goals.